Performing and interpreting randomized clinical trials
نویسندگان
چکیده
منابع مشابه
Interpreting and reporting clinical trials with results of borderline significance.
The quality of randomised clinical trials and how they are reported have improved over time, with clearer guidelines on conduct and statistical analysis.Clinical trials often take several years, but interpreting the results at the end is arguably the most important activity because it influences whether a new intervention is recommended or not. Although researchers have becomemore familiar with...
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Heart Failure With Preserved Ejection Fraction Heart failure with preserved ejection fraction (HFpEF) or diastolic heart failure (HF) accounts for approximately half of HF cases in the community, and the portion of HF with preserved ejection fraction (EF) is increasing. Patients with HFpEF have limited functional capacity and poor prognosis. With ongoing shifts in the age distribution of the po...
متن کاملBlindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
متن کاملPerforming meta-analysis with incomplete statistical information in clinical trials
BACKGROUND Results from clinical trials are usually summarized in the form of sampling distributions. When full information (mean, SEM) about these distributions is given, performing meta-analysis is straightforward. However, when some of the sampling distributions only have mean values, a challenging issue is to decide how to use such distributions in meta-analysis. Currently, the most common ...
متن کاملTRIALS ON TRIAL Interpreting the results of a clinical trial
Elements of an interpretation Authors are generally encouraged to summarise which the results and findings are consistent with hypothesis, and to comment on the robustness of drawing conclusions and making recommendations n ex pla I preparing an article reporting a clinical trial, the authors are pected to provide a reasoned interpretation of the results and ce them into a broader clinical cont...
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ژورنال
عنوان ژورنال: Journal of Osteopathic Medicine
سال: 2021
ISSN: 2702-3648
DOI: 10.1515/jom-2020-0320